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Esistono molteplici pubblicazioni di studi che hanno provato gli effetti benefici della pratica del digiuno. In questa pagina la lista di referenze verrà completata periodicamente. Seguite il nostro bollettino!

Qui di seguito i link per gli articoli pubblicati (quando possibile secondo i diritti di proprietà) o per i riassunti pubblicati su pubmed.


Brandorst S, Longo VD. Dietary restrictions and nutrition in the prevention and treatment of cardiovascular disease. Circulation Research, 2019.

Brandorst S, Longo VD. Protein Quantity and Source, Fasting-Mimicking Diets, and Longevity. Advances in Nutrition, 2019.

De Cabo R, Mattson MP. Effects of Intermittent Fasting on Health, Aging, and Disease. New England Journal of Medicine, 2019.

Nencioni A et al. Fasting and cancer: molecular mechanisms and clinical application. Nature Reviews Cancer, 2018.

Clinical studies

Caffa I et al. Fasting-mimicking diet and hormone therapy induce breast cancer regression. Nature, 2020.

De Groot et al. Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial. Nature Communications, 2020.

Maniaci G et al. Efficacy of a fasting-mimicking diet in functional therapy for depression: A randomised controlled pilot trial. Journal of Clinical Psychology, 2020.

Zorn S et al. Impact of modified short-term fasting and its combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients – a controlled cross-over pilot study. BMC Cancer, 2020.

Bauersfeld SP et al. The effects of short-term fasting on quality of life and tolerance to chemotherapy in patients with breast and ovarian cancer: a randomized cross-over pilot study. BMC Cancer, 2018.

De Braud et al. Metabolic and immunologic effects of the fasting mimicking diet in cancer patients. In: Proceedings of the AACR-NCI-­EORTC international conference, 2017: Abstract B022.

Li C et al. Effects of a one-week fasting therapy in patients with type-2 diabetes mellitus and metabolic syndrome - a randomized controlled explorative study. Experimental and Clinical Endocrinology & Diabetes, 2017.

Wei et al. Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science Translational Medicine, 2017.

Dorff TB et al. Safety and feasibility of fasting in combination with platinum-based chemotherapy. BMC Cancer, 2016.

Song M et al. Association of Animal and Plant Protein Intake With All-Cause and Cause-Specific Mortality. JAMA Internal Medicine, 2016.

De Groot S et al. The effects of short-term fasting on tolerance to (neo) adjuvant chemotherapy in HER2-negative breast cancer patients: a randomized pilot study. BMC Cancer, 2015.

Levine ME et al. Low protein intake is associated with a major reduction in IGF-1, cancer, and overall mortality in the 65 and younger but not older population. Cell Metabolism, 2014.

Safdie FM et al. Fasting and cancer treatment in humans: a case series report. Aging (Albany NY), 2009.

Preclinical studies

Ajona D et al. Short-term starvation reduces IGF-1 levels to sensitize lung tumors to PD-1 immune checkpoint blockade. Nature Cancer, 2020.

Di Tano et al. Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers. Nature Communications, 2020.

Lévesque S et al. A synergistic triad of chemotherapy, immune checkpoint inhibitors, and caloric restriction mimetics eradicates tumors in mice. Oncoimmunology, 2019.

Rangan P et al. Fasting-mimicking diet modulates microbiota and promotes intestinal regeneration to reduce inflammatory bowel disease pathology. Cell Reports, 2019.

Cheng C et al. Fasting-mimicking diet promotes Ngn3-driven β-cell regeneration to reverse diabetes. Cell, 2017.

Lo Re O et al. Fasting inhibits hepatic stellate cells activation and potentiates anti-cancer activity of Sorafenib in hepatocellular cancer cells. Journal of Cellular Physiology, 2017.

Choi IY et al. A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms. Cell Reports, 2016.

Di Biase S et al. Fasting-mimicking diet reduces HO-1 to Promote T cell-mediated tumor cytotoxicity. Cancer Cell, 2016.

Brandhorst et al. A Periodic Diet that Mimics Fasting Promotes Multi- System Regeneration, Enhanced Cognitive Performance, and Healthspan. Cell Metabolism, 2015.

Caffa I et al. Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition. Oncotarget, 2015.

Cheng C et al. Prolonged fasting reduces IGF-1/PKA to promote hematopoietic-stem-cell-based regeneration and reverse immunosuppression. Cell Stem Cell, 2014.

Lee C et al. Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy. Science Translational Medicine, 2012.

Safdie F et al. Fasting enhances the response of glioma to chemo- and radiotherapy. PLOS one, 2012.

Shi Y et al. Starvation-induced activation of ATM/Chk2/p53 signaling sensitizes cancer cells to cisplatin. BMC Cancer, 2012.

Lee C et al. Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Research, 2010.

Raffaghello L et al. Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy. PNAS, 2008.

Shanley DP, Caloric restriction and aging: a life-history analysis. Evolution, 2000.